At least two people were killed and 22 hurt in a shooting at a house party packed with young adults near Houston, Texas, police told US media Sunday.

Police are looking for two suspects in connection with the shooting late Saturday in Cypress, a suburb of Houston, Christina Garza at the Harris County Sheriff's Department told CNN.

"We have not been able to talk to a lot of the witnesses, because of the nature of their injuries. But we don't have any shooters in custody," Garza told CNN.

One person died in the house and the other died in the hospital, Garza said.

Those hurt were rushed to the hospital, though it's still unclear how many of those have gunshot wounds and how many were injured in the stampede to flee the shooting.

"As you can imagine, this was chaos in a residential neighborhood. This was a private home where they were hosting a house party," Garza said.

There were at least 22 people rushed to five area hospitals, though some had minor injuries, the Houston Chronicle reported, citing the sheriff's office.

More than 100 people were at the house celebrating a birthday, the Chronicle said.

Garza said that there was at least one adult in the house at the time, and that most partygoers were older teens, with some in their early 20s.

The shooting broke out Saturday around 11:30 pm (0530 GMT Sunday), Garza told CNN. (AFP)