Israeli forces shot and killed a teenage Palestinian protester during a clash in the West Bank late Wednesday, raising tensions already heightened by the death of a Palestinian prisoner and renewed fighting between Israel and Gaza militants.

The late night killing capped a day of rioting throughout the West Bank in protest at the prisoner's death from cancer and raised the likelihood of further unrest in the Palestinian territories Thursday.

Mohammed Ayyad, a spokesman for the Palestinian Red Crescent, said a 17-year-old Palestinian was killed in a clash between the Israeli army and Palestinian stone-throwers at a checkpoint near the West Bank city of Tulkarem. He was hit by a bullet in the chest, Ayyad said. The spokesman did not provide the youth's name.

The Israeli military said several Palestinians hurled firebombs at a military post near Tulkarem, and soldiers at the post fired a live round at the protesters, hitting one. The army said it was reviewing the circumstances of the incident.

Early Wednesday, Palestinian militants launched several rockets into southern Israel and Israeli aircraft struck targets in the Gaza Strip in the heaviest exchange of fire between the sides since a cease-fire ended a major flare-up last year.

There were no casualties, but the violence nonetheless threatened to shatter the calm that has prevailed for more than four months. Israel's new defense minister issued a stern warning.

“We will not allow shooting of any sort (even sporadic) toward our citizens and our forces,” Moshe Yaalon, a former military chief of staff, said in a statement.

By nightfall Wednesday, calm appeared to have returned on that front. A small al-Qaida-influenced group was suspected. The rocket fire coincided with unrest in the West Bank over the death of a Palestinian prisoner.

Yaalon said he holds the Islamic militant Hamas, which has ruled Gaza since 2007, responsible for all such attacks from the seaside strip.

Israel launched an offensive against Hamas last November in response to an increase in rocket fire from Gaza. During eight days of fighting, Israel carried out hundreds of airstrikes in Gaza, while Gaza militants fired hundreds of rockets into Israel. More than 160 Palestinians, including dozens of civilians, and six Israelis were killed in the fighting before Egypt brokered a truce.

In recent weeks, there have been several rocket attacks, including one as President Barack Obama was visiting Israel two weeks ago. Overnight Wednesday, Israel responded for the first time by striking a pair of empty fields in northern and eastern Gaza.

Around the time Yaalon was speaking on Wednesday morning, two more rockets exploded in the Israeli border town of Sderot, according to police. Air raid sirens sounded, and people on their way to work and school took cover. No injuries were reported.

The Israeli military said a total of five rockets were fired within 24 hours, including two that exploded prematurely inside Gaza.

Under the cease-fire, Israel pledged to halt its policy of attacking militant leaders and to ease a blockade it imposed on Gaza after the Hamas takeover in 2007. Hamas pledged to halt rocket attacks on Israel. A number of smaller militant groups also operate in Gaza, including groups that draw inspiration from the al-Qaida global terror network.

U.N. Mideast envoy Robert Serry appealed for calm in a statement. “It is of paramount importance to refrain from violence in this tense atmosphere and for parties to work constructively in addressing the underlying issues,” he said.

Ihab Ghussein, the Hamas government spokesman, accused Israel of using the airstrikes to “divert the attention” from unrest in Israeli prisons.

Palestinian prisoners have been rioting and hunger striking since a 64-year-old prisoner died of throat cancer on Tuesday. Palestinians blamed Israel for the man's death, saying he was not given proper medical care. The prisoner, Maysara Abu Hamdiyeh, was serving a life sentence for his role in a foiled attempt to bomb a busy cafe in Jerusalem in 2002.

Einav Shimron Grinbaum, spokeswoman of Israel's health ministry, said an autopsy performed Wednesday found a cancerous growth in Abu Hamdiyeh's throat and secondary cancerous growths in his neck, chest, lungs, liver, and spinal cord. She said hospital records showed he was a heavy smoker. The head of the Palestinian pathological institute also participated in the autopsy, she said.

At protests across the West Bank Wednesday afternoon, hundreds of Palestinians threw rocks and rolled burning tires at soldiers, prompting a response with tear gas, the Israeli military said.

In Ramallah, protesters waved pictures of Abu Hamdiyeh and chanted “with our souls and blood we will redeem the prisoner.”

Israel's chief military spokesman, Brig. Gen. Yoav Mordechai, accused the Palestinian Authority, which governs in the West Bank, of exploiting the death to “resume popular protests.”

Prisons Authority spokeswoman Sivan Weizman said Abu Hamdiyeh was treated by Israeli specialists and died in a hospital in Beersheba.

Weizman said almost all of the 4,600 Palestinian prisoners detained by Israel refused their breakfasts Wednesday morning in a symbolic act of protest.

In a separate development, Israel's defense minister issued a tough warning to battling forces in Syria, saying Israel would respond to any cross-border provocations.

On Tuesday, the Israeli military said a mortar shell exploded on its side of the frontier in the Golan Heights. The military said its soldiers returned the fire and said they scored a direct hit.

“Israel has no intention of ignoring fire from Syria toward Israeli territory, incidental or not, and will respond with a firm hand,” Yaalon said. “As far as we are concerned, the Syrian regime is to be held responsible for everything happening in its territory.”

Israel, which has warily watched the fighting in Syria raging close to its frontier, is concerned that al-Qaida-linked groups fighting alongside the rebels could set their sights on Israel after the civil war ends. (AP)