DELRAY BEACH, Florida (AP) ― Andy Roddick reached his second quarterfinal of the year with a 6-4, 7-5 victory over Denis Istomin of Uzbekistan at the Delray Beach International Tennis Championship on Thursday.

The other time the fourth-seeded Roddick reached a quarterfinal this season was in San Jose two weeks ago. He lost that match to Istomin 6-2, 6-4 in their only other career meeting.

Roddick is currently ranked No. 30, which is the lowest ranking he’s had since he ranked No. 30 on Aug. 13, 2001. He’s been dealing with right hamstring and right ankle problems this year and he’s struggling to find a range with his game.

Roddick only delivered on 50 percent of his first serves against the 51st-ranked Istomin.

“I’m feeling better than I did a couple of matches ago,” Roddick said. “I served horrendously and still won and was still able to break serve.”

Roddick offered Istomin five chances to break serve, but Istomin only successfully broke serve in the eighth game of the first set.

In the second set, Istomin led in the 11th game by 40-15 but then made four consecutive unforced errors to hand Roddick the service break.

Roddick managed to serve out the match in the next game, but he had to fight to close the match. He faced three break points and needed two match points before Istomin sailed a forehand long to end the match.

“I got it done in the end,” Roddick said. “You want to close. I thought the misses I had were positive misses because they were played on my terms.

“I think that was a big step.”

Roddick will play seventh-seeded Kevin Anderson of South Africa in the quarterfinals.

Anderson topped Xavier Malisse of Belgium 6-3, 3-6, 6-3. The 6-foot-8 Anderson had nine aces and won 77 percent of his first serve points, although his first serve percentage was only 55 percent.

“I thought it really gusty, really windy, and it wasn’t easy to get a good rhythm,” Anderson said. “I thought it was tough for both of us because we couldn’t play the kind of tennis we wanted to play.”

Malisse was a two-time former Delray Beach champion (2005 and ‘07) and came into the match with a 25-9 record at this tournament. He did well when his forehand was kicking in, but otherwise struggled.

Anderson will play the winner of Thursday night’s match between fourth-seeded Andy Roddick and Denis Istomin of Uzbekistan in the quarterfinals.

Roddick, who grew up in South Florida, lost to Istomin the one time they’ve played in the San Jose quarterfinals last month.

Fifth-seeded Philipp Kohlschreiber of Germany also advanced to Friday’s quarterfinals. He defeated 57th-ranked Ivan Dodig of Croatia 6-2, 6-2.

Kohlschreiber saved both break points he faced on serve and took advantage of four of 10 break point opportunities he had on Dodig’s serve. Kohlschreiber broke serve in the fifth and seventh games of the first set and the third and seventh games of the second set.

Kohlschreiber is now 12-5 in 2012 and has reached the semifinals in Auckland and Montpellier, France.

The German’s quarterfinal opponent will be Dudi Sela of Israel, who earned his quarterfinal spot with a 6-4, 6-4 win over Jarkko Nieminen of Finland.

Sela, who also reached the Chennai quarterfinals this season, won 25 of the 30 points when his first serve went into play.

“It was difficult conditions because the wind was swirling,” said Sela, who said the weather is similar to what he’s used to in Israel.

“It was tough to serve and you had to put your first serves in. I think I served very well and I didn’t give him any presents.”